It means "owned," like dominated, made to look silly, etc.
I assume the derivation is from someone accidentally typing a 'p' for an 'o' (next to each other on the keyboard) somewhere famously and then it spreading from there.
Nathan is supposed to test it this Saturday and then have the surgery next week unless he's made a miraculous recovery (less than a 1% chance, I'd have to say.) Jesse Crain the closer?